Framework for botnet emulation and analysis

Criminals use the anonymity and pervasiveness of the Internet to commit fraud, extortion, and theft. Botnets are used as the primary tool for this criminal activity. Botnets allow criminals to accumulate and covertly control multiple Internet-connected computers. They use this network of controlled computers to flood networks with traffic from multiple sources, send spam, spread infection, spy on users, commit click fraud, run adware, and host phishing sites. This presents serious privacy risks and financial burdens to businesses and individuals. Furthermore, all indicators show that the problem is worsening because the research and development cycle of the criminal industry is faster than that of security research. To enable researchers to measure botnet connection models and counter-measures, a flexible, rapidly augmentable framework for creating test botnets is provided. This botnet framework, written in the Ruby language, enables researchers to run a botnet on a closed network and to rapidly implement new communication, spreading, control, and attack mechanisms for study. This is a significant improvement over augmenting C++ code-bases for the most popular botnets, Agobot and SDBot. Rubot allows researchers to implement new threats and their corresponding defenses before the criminal industry can. The Rubot experiment framework includes models for some of the latest trends in botnet operation such as peer-to-peer based control, fast-flux DNS, and periodic updates. Our approach implements the key network features from existing botnets and provides the required infrastructure to run the botnet in a closed environment.Ph.D.Committee Chair: Copeland, John; Committee Member: Durgin, Gregory; Committee Member: Goodman, Seymour; Committee Member: Owen, Henry; Committee Member: Riley, Georg

ANALYSIS AND QUANTIFICATION OF HAZARDS ASSOCIATED WITH CASCADING THERMAL RUNAWAY PROPAGATION IN LITHIUM ION BATTERY CELL ARRAYS

Lithium ion batteries are among the most common and efficient electrical energy storage devices despite the thermal, fire, and chemical hazards they pose upon thermal failure due to abnormal conditions. The hazards are intensified when thermal failure propagates from a single cell to neighboring cells in a battery pack. A new wind tunnel experimental setup was designed and built to investigate the dynamics, gaseous emissions, and energetics of cascading failure propagation in 18650 form factor, 2600 mA h, lithium cobalt oxide cathode cell arrays. Ambient environment (N2 / air), cell state of charge (SOC; 50% / 100%), and cell arrangement (without 5 mm gaps between cell rows / with 5 mm gaps between cell rows) were all varied during tests to investigate different aspects of battery pack failure and quantify the impact of different failure mitigation strategies. On average, failure propagation speed was 7.5 times faster in air than in nitrogen, 8.5 times slower at 50% SOC than at 100% SOC, and three times slower with a 5 mm gap between cells than without it. All tested cell arrays ejected minor mass yields of O2 and H2, as well as comparatively large mass yields of total unburned hydrocarbons, CO and CO2. At 100% SOC, approximately 59 kJ of energy per cell was produced from the chemical reactions between cell components during failure. An additional 62.8 ± 18.4 kJ per cell was produced when the ejected battery materials during failure combusted in a reacting medium, but the combustion in the wind tunnel setup was highly incomplete due to the development of under-ventilated conditions. In a separate experimental setup with near complete combustion, combustion energy of 107 ± 17.7 kJ per cell was measured

Motor cortex organization after stroke is related to side of stroke and level of recovery.

The present study hypothesized that side of stroke and level of recovery influence motor system organization after stroke.Functional MRI was performed on 14 control subjects and 21 patients with chronic stroke during index finger tapping (control subjects, right; patients, recovered side).On functional MRI, stroke patients with right arm involvement showed (1) significantly smaller activation in contralateral motor cortexes compared with control subjects; (2) smaller ipsilateral (nonstroke) premotor and larger contralateral (stroke-side) sensorimotor activation compared with patients with left arm involvement, although electromyogram across groups was similar; and (3) 2.7-fold-larger contralateral sensorimotor cortex activation, ventrally, in those with full recovery compared with those with partial recovery, despite similar tapping force, frequency, range of motion, and electromyogram between groups. Supplementary motor area activation was unrelated to level of recovery.After stroke that causes mild to moderate initial impairment and mild residual hand weakness, cortical organization varies with side of injury and with final motor status. The findings may have implications for treatment after stroke

Roof Robot 3

In 2006 through 2008 two teams of students developed an all-wheel drive robot capable of traversing a variety of roof geometries while visually displaying roof conditions for a sponsor. Our team performed numerous enhancements on the previous years\u27 designs in order to grant the robot superior traction as well as an improved range and mobility, allowing the robot to operate over the crest of a roof. A new microcontroller and Wi-Fi camera were implemented to allow for two way communication between the robot and a computer, and to allow for a reliable video feed. A single man operable ascender system was designed that is able to be transported in a minivan and able to allow the robot access to a second story roof

A rotary mechanism for allostery in bacterial hybrid malic enzymes

This project was funded by BBSRC studentship 1500753 to C.J.H. and a BBSRC David Phillips fellowship to P.J.M. (BB/S010122/1).Bacterial hybrid malic enzymes (MaeB grouping, multidomain) catalyse the transformation of malate to pyruvate, and are a major contributor to cellular reducing power and carbon flux. Distinct from other malic enzyme subtypes, the hybrid enzymes are regulated by acetyl-CoA, a molecular indicator of the metabolic state of the cell. Here we solve the structure of a MaeB protein, which reveals hybrid enzymes use the appended phosphotransacetylase (PTA) domain to form a hexameric sensor that communicates acetyl-CoA occupancy to the malic enzyme active site, 60 Å away. We demonstrate that allostery is governed by a large-scale rearrangement that rotates the catalytic subunits 70° between the two states, identifying MaeB as a new model enzyme for the study of ligand-induced conformational change. Our work provides the mechanistic basis for metabolic control of hybrid malic enzymes, and identifies inhibition-insensitive variants that may find utility in synthetic biology.Publisher PDFPeer reviewe

Reproduction, Embryonic Development, and Maternal Transfer of Contaminants in the Amphibian Gastrophryne carolinensis

Although many amphibian populations around the world are declining at alarming rates, the cause of most declines remains unknown. Environmental contamination is one of several factors implicated in declines and may have particularly important effects on sensitive developmental stages. Despite the severe effects of maternal transfer of contaminants on early development in other vertebrate lineages, no studies have examined the effects of maternal transfer of contaminants on reproduction or development in amphibians. We examined maternal transfer of contaminants in eastern narrow-mouth toads (Gastrophryne carolinensis) collected from a reference site and near a coal-burning power plant. Adult toads inhabiting the industrial area transferred significant quantities of selenium and strontium to their eggs, but Se concentrations were most notable (up to 100 μg/g dry mass). Compared with the reference site, hatching success was reduced by 11% in clutches from the contaminated site. In surviving larvae, the frequency of developmental abnormalities and abnormal swimming was 55–58% higher in the contaminated site relative to the reference site. Craniofacial abnormalities were nearly an order of magnitude more prevalent in hatchlings from the contaminated site. When all developmental criteria were considered collectively, offspring from the contaminated site experienced 19% lower viability. Although there was no statistical relationship between the concentration of Se or Sr transferred to eggs and any measure of offspring viability, our study demonstrates that maternal transfer may be an important route of contaminant exposure in amphibians that has been overlooked

A Catalogue of RR Lyrae Stars from the Northern Sky Variability Survey

A search for RR Lyrae stars has been conducted in the publicly available data of the Northern Sky Variability Survey (NSVS). Candidates have been selected by the statistical properties of their variation; the standard deviation, skewness and kurtosis with appropriate limits determined from a sample 314 known RRab and RRc stars listed in the GCVS. From the period analysis and light curve shape of over 3000 candidates 785 RR Lyrae have been identified of which 188 are previously unknown. The light curves were examined for the Blazhko effect and several new stars showing this were found. Six double-mode RR Lyrae stars were also found of which two are new discoveries. Some previously known variables have been reclassified as RR Lyrae stars and similarly some RR Lyrae stars have been found to be other types of variable, or not variable at all.Comment: Accepted for publication in MNRAS. Tables 1 and 2 are available here in full, but not in the printed editio

Exercise training for intermittent claudication:a narrative review and summary of guidelines for practitioners

Peripheral artery disease (PAD) is caused by atherosclerotic narrowing of the arteries supplying the lower limbs often resulting in intermittent claudication, evident as pain or cramping while walking. Supervised exercise training elicits clinically meaningful benefits in walking ability and quality of life. Walking is the modality of exercise with the strongest evidence and is recommended in several national and international guidelines. Alternate forms of exercise such as upper- or lower-body cycling may be used, if required by certain patients, although there is less evidence for these types of programmes. The evidence for progressive resistance training is growing and patients can also engage in strength-based training alongside a walking programme. For those unable to attend a supervised class (strongest evidence), home-based or ‘self-facilitated’ exercise programmes are known to improve walking distance when compared to simple advice. All exercise programmes, independent of the mode of delivery, should be progressive and individually prescribed where possible, considering disease severity, comorbidities and initial exercise capacity. All patients should aim to accumulate at least 30 min of aerobic activity, at least three times a week, for at least 3 months, ideally in the form of walking exercise to near-maximal claudication pain

The Star Formation Rate Function of the Local Universe

We have derived the bivariate luminosity function for the far ultraviolet (1530Angstroms) and far infrared (60 microns). We used matched GALEX and IRAS data, and redshifts from NED and PSC-z. We have derived a total star formation luminosity function phi(L_{tot}), with L_{tot} = L_{FUV}+L_{FIR}. Using these, we determined the cosmic ``star formation rate'' function and density for the local universe. The total SFR function is fit very well by a log-normal distribution over five decades of luminosity. We find that the bivariate luminosity function phi(L_{FUV},L_{FIR}) shows a bimodal behavior, with L_{FIR} tracking L_{FUV} for L_{TOT}< 10^10 L_sun, and L_{FUV} saturating at 10^10 L_sun, while L_{TOT} L_{FIR} for higher luminosities. We also calculate the SFR density and compare it to other measurements.Comment: This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200